Under Part 107, a person may not act as a remote pilot in command if they know or have reason to know they have a physical or mental condition that:

Why →Under 14 CFR § 107.17, no person may act as remote PIC if they know or have reason to know of any physical or mental condition that would interfere with the safe operation of the small UAS. There is no medical certificate required under Part 107, but self-assessment is mandatory.

The trap →Part 107 requires no FAA medical certificate and no medication disclosure. That's a manned aviation requirement. The standard here is purely self-assessed: would this condition interfere with safe operation?

Field note →This includes fatigue, alcohol (8-hour "bottle to throttle" rule applies under § 107.27), and any impairing medication. When in doubt, don't fly.